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The principal cytochrome P450 isoenzyme involved seems to get CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Close to eighty five% of an oral dose appears within the urine in 24 hrs of administration, most given that the glucuronide conjugate, with little quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity details.Abu